I-Lipoprotein (a), eyaziwa nangokuthi yi-Lp (a), i-lipoprostin ephantsi (i-LDL, okanye "i-cholesterol" embi) enomnye uhlobo lweprotheni, obizwa ngokuba yi-glycoprotein, ehlanganiswe kuyo. (Igama le glycoprotein yiapolipoprotein (a). )
Abaphandi basebenzela ukuqonda ipoprotein (a) kunye neendlela ezichaphazela ngayo impilo yakho. Nangona kunjalo, uphando oluthile lubonisa ukuba ukuphakama kweepoprotein (a) ukujikeleza egazini lakho kunokukubeka emngciphekweni ophezulu wokuphuhlisa isifo senhliziyo .
Yintoni i-Lipoprotein (a) Ngaba
Yenziwe esibindi sakho kwaye ingena kwigazi lakho, i-lipoprotein (a) iboniswe ukwakha phantsi kwebhanki elingaphakathi leetriyri. Lo mhlaba unokuba negalelo ekuphuhliseni i-atherosclerosis-inkcazelo yamatye enamafutha emithonjeni yakho engakhokelela kwizifo zentliziyo, ukuhlaselwa yintliziyo, kunye nokubetha-ngokukhuthaza ukuvutha komzimba (ubomvu nokuvuvukala) kunye nokwakhiwa kwamaseli e-foam, iiseli ezinamafutha ezinamathele i-atherosclerotic plaques. Ukwengeza:
- Amanqanaba aphakamileyo e-lipoprotein (a) akholelwa ukuba awonakalisa kakhulu kwiindonga zearteri xa izinga lomntu we-LDL ("bad") le-cholesterol liphezulu.
- Iipheropoprotein eziphezulu (a) ziye zaboniswa ukunciphisa amathuba okuphila kumntu ohlaselwe yintliziyo.
Amanqanaba aqhelekileyo
Ukuhlolwa kwegazi kufunyanwe kumanqanaba eepoprostin (a) kuboniswa kwi-milligram nge-deciliter (mg / dL). Inqanaba lika-30 mg / dL lijongwa njengeqhelekileyo. Iziphumo eziphezulu kunama-30 mg / dL zingabonisa ukuba u-2 ukuya kwe-3 unobungozi obunobungozi besifo senhliziyo.
Nangona kunjalo, i-lipoprotein (a) amanqanaba ayingxenye yolu vavanyo lwegazi lwepiliti yepilisi, elinezilinganiso zamanqanaba e- cholesterol , i-LDL, ne-HDL ye-cholesterol, kunye ne-triglycerides (uhlobo lwamafutha atholakala kuwo wonke umzimba). Kungenxa yokuba 1) ayanele ngokwaneleyo malunga neepoprotein (a) entle kwimpilo yentliziyo kunye no-2) kufumaneka kuphela kwi-15% yabantu bonke, kunye nabantu abavela kwi-Caucasian, isiTshayina kunye neJapan abavela kwizona ziphantsi amanqanaba.
Oko kwathiwa, kukho iimeko ezimbalwa apho kungcono ukuhlolisisa i-lipoprotein (a) amanqanaba. Eyona nto, xa umntu ekhona:
- Izifo zentliziyo eyaziwayo kunye namazinga aqhelekileyo ye-HDL, i-LDL, kunye ne-triglycerides
- Imbali yentsapho eqinile yesifo senhliziyo kodwa, kwakhona, i-HDL, i-LDL, kunye ne-triglyceride
- Ukuqhubeka kwamanqanaba aphezulu e-LDL naphezu kokufumana unyango
Ngaba kufuneka uzame ukunciphisa amanqanaba akho?
Ngelishwa, kuba ama-lipoprotein (a) amanqanaba aphembelele kakhulu kwiijeni zakho, iziphakamiso eziqhelekileyo-ukutya okunempilo, ukuzivocavoca rhoqo, kunye (ezininzi) i- cholesterol-yokunciphisa imishanguzo -sinokuba nefuthe elikhulu ekunciphiseni. U-Niacin ubonise isithembiso esithile kwizifundo zekliniki zokunciphisa iipoprotein (a) amanqanaba. Nangona kunjalo, ayilisebenzisiyo rhoqo loo njongo.
Ukuba uzama ukunciphisa umngcipheko wokuba nesifo senhliziyo, kukulungele ukubeka i-lipoprotein (a) kwonyango "umtshini wokutsha" ngoku kwaye ugxininise iindlela zokunciphisa iimeko ezinobungozi zesifo senhliziyo. Njengoko mhlawumbi uyazi, ezi ziquka ukunciphisa uxinzelelo lwegazi xa luphezulu kakhulu, linciphisa i-cholesterol ye-LDL ephakamileyo kunye nokuphakamisa i-cholesterol ye-HDL ephantsi. Izifundo ezininzi zibonise ukuba ukujoliswa kwezi zinto ezinobungozi kunokuncedisa ukunciphisa umngcipheko wokuba nesifo senhliziyo okanye ukubetha.
Imithombo:
Erquo S, Kaptoge S, uPerry PL et al. I-Lipoprotein (a) uxinzelelo kunye nomngcipheko we-coronary disease disease, ukuphazamiseka komzimba kunye nokungafi. JAMA 2009; 302: 412-423.
I-Boffa MB, iKoschinsky ML, iBerglund L. Lipoprotein (a): into ekhethekileyo yengozi yesifo senhliziyo. I-Lab Lab Med 2006; 26: 751-772.
I-ID yovavanyo: I-LIPA-lipoprotein (a) i-serum. "I-Mayo Clinic-iMayo Laboratories (2016).
Kang S. "Yintoni i-lipoprotein (a) kwaye ithetha ntoni kuwe?" I-HealthCentral (2008).