Amajethi owawuzuze kubazali bakho achaza ukubonakala komzimba wakho, njengombala wamehlo kunye neentlobo, kunye nezinye iimpawu, njengoluhlobo lwegazi kunye nokujonga kwangaphambili. Kwaye akunjalo. Izaziso ezizalwe ziza kunceda ukunquma ezinye izixhobo zomzimba wakho - ezifana nokuthintela umdlavuza weprotate ukuphindaphinda.
Indlela iCrostate Cancer ikhula ngayo
I-Androgens (i-hormone yesini) yenza umdlavuza we-prostate ukhule.
Ngoko ke, i- androgen unyango lokunyanga (ADT) yindlela enye yokunyanga umdlavuza we-prostate , ngokukodwa xa uphumelele okanye usasazeka. I-ADT inokubandakanya ukuthatha amayeza anqanda i-androgen ukuba iveliswe (kumathambo) okanye uvimbele umphumo we-androgen kuwo wonke umzimba wakho. I-ADT nayo inokubandakanya utyando ekukhutsheni amacwecwe omabini. Ngokuqhelekileyo kusetyenziselwa ukongeza kwezinye iindlela zokwelapha umdlavuza we-prostate, njengokwelashwa kwe-radiation okanye ukususwa kweprotate.
I-ADT, ngokuyinene, isusa amafutha kunye nokuyeka iintsholongwane zomhlaza wesifo sesifo sesifo se-prostate ukusuka ekukhuleni- okanye ubuncinci.
Kodwa, kwiimeko ezininzi, i-ADT isebenza kuphela ixesha elide. Amaseli omhlaza wesifo seprotate ngokuqhelekileyo abe "ukuxhatshazwa ngokukodwa" ekugqibeleni. Baqala ukwenza i-androgen yabo, ngaloo ndlela bazinyusa.
Amadoda athola i-ADT yesifo somhlaza wesifo seprotate aneemvavanyo rhoqo ze- prostate-specific antigen (PSA) . Ukunyuka kwamazinga e-PSA kunokubonisa ukuba umdlavuza we-prostate uye waxhatshazwa kwaye uqale ukukhula kwakhona.
Izifo zeGenesis Qinisekisa Amandla akho okulwa neCarstate Cancer
Amanye amadoda angasebenzisa i-ADT ukuba agcine umdlavuza wesifo sophethiza kwixesha elide kunezinye.
Ucwaningo lwe-2016 kwikliniki yaseCleveland kunye neKliniki yaseMayo yabona ukuba amadoda anesimo esithile salo geni athile angakwazi ukufumana umdlavuza we-prostate ongagwenxa ngokukhawuleza. Kula madoda, i-ADT ayisebenzi kangangoko.
Umhlaza wabo uza kuphinda unyuke ngokukhawuleza.
Ku-443 izigulane zomhlaza zesifo seprotate kwisifundo, zonke izifo ziqhubekile kwaye zaphathwa nge-ADT. Amanye amadoda "aqhelekileyo" amagciwane e-HSD3B1 - iikopi ezimbini, omnye kumzali ngamnye. Abanye babenokuhluka, i- HSD3B1 (1245C), kodwa kuphela kumzali omnye. Kanti abanye babenomdla wohlobo oluhlukileyo kubazali bobabini.
Iikopi ezininzi ze-gene ehlukile, i-ADT engaphantsi yasebenza.
Labo abaneengqungquthela "eziqhelekileyo" kwiCleveland Clinic iqela lezigulane bayeka umhlaza wesibeleko ukuba uphinde ube ngumyinge wama-6.6 iminyaka. Abanye abazange baphumelele. Labo abanomdla wokuhlukumeza komnye umzali baphinde baphinde baphinde baphumelele kwiminyaka engama-4.1. Labo abanomdla wokuhlukumeza abavela kubazali bobabini babambelela ngokuphindaphindiweyo kwiminyaka engama-2.5 kuphela.
Ngaba Unayo I-Gene Variant?
Ngokutsho kweprojekthi ye-Genomes yase-1000, malunga nesigamu samadoda kunye nabasetyhini base- US bane-gene HSD3B1 (1245C) -bavela kubazali okanye bobabili abazali.
Okwangoku, akukho vavanyo olulula ukuluchonga (nangona lungafumaneka kwipaneli epheleleyo yezofuzo). Uphando olungakumbi lufunekayo phambi kokuba uvavanyo lwegazi lwe - HSD3B1 (1245C) lwenziwa ngokubanzi.
Kutheni ngoku? Ngenxa yokuba akukho ubungqina obanele ukuba ukutshintsha unyango kubayeni abanomdla wokuhluka kuya kuphucula iziphumo.
Senza uphando olongezelelweyo ngoku ukujonga ukuba ezinye iindlela zokwelapha i-hormone ziya kusebenza kangcono kune-ADT kula madoda. Ukuba benza, siya kuba nobungqina bokuba ukuhlolwa kwegazi okulula kufuneka kunikwe isikrini kwiHSD3B1 (1245C).
Ukwelashwa okwenziwe ngabanye kunokuphumelela ngakumbi
Namhlanje siphatha zonke izigulane ezineomhlaza womhlaza wesifo se-prostate ngokuhambelana nomgangatho omnye wokunyamekela. Kodwa uphando lunokusishukumisela ukuba sibhekiselele kwiinkqubo zonyango ezisekelwe kwiimpawu zofuzo zesigulane.
Kwixesha elizayo kungekude kakhulu, sinethemba lokusebenzisa uvavanyo lofuzo ukuze sigqibe ukuba zeziphi izigulana zifuna ukuphi unyango, endaweni yokunyanga wonke umntu ofanayo.
Ngokomzekelo, izigulane ezingenayo i- HSD3B1 (1245C) i-gene ingahamba kakuhle ne-ADT. Abo bahamba nabo bangadinga unyango olungakumbi.
UDkt. Sharifi uyigqirha yezokwelapha kwiCleveland Clinic yaseTaussig Cancer Institute kwaye ibamba uSihlalo weKendrick Family onikezelwe nguPhando lweCarstate Clinic eCliniveland Clinic.
> Imithombo:
> Hearn JW, Abuali G, Reichard CA, et al. HSD3B1 kunye nokuxhatshazwa kwe-androgen-unyango lokunyanga kwi-prostate cancer: i-retrospective, i-multicohort. Lancet Oncol. 2016; 17 (10): 1435-1444.