Sekunjalo ngenye imfihlelo, i-sarcoidosis isifo esingaziwayo-nangona iimpendulo zokuzivikela komzimba kunye neengxaki zomzimba zomntu zikholelwa ukuba zibalulekile. I-Sarcoidosis, ngamanye amaxesha ebizwa ngokuba yi-sarcoid, ikhokelela kwisimo sokuvuvukala esibonakala phantsi kwe-microscope kwaye sinokuchaphazela izitho ezahlukeneyo zomzimba. I-Sarcoidosis inokuchaphazela nayiphi na inxalenye, kodwa kunokwenzeka ukuba inokuchaphazela ezi zilandelayo:
- Imiba
- Isikhumba
- I-lymph nodes - ngakumbi i- lymph nodes kwisifuba
I-Sarcoidosis yaziwa nangokuthi iyakwazi ukuchaphazela amehlo kunye nesibindi. Ngokuqhelekanga, intliziyo nengqondo zichaphazelekayo, zikhokelela kwiingxaki ezinzulu.
Ukususela kumbono weeseli kunye nezicubu, uphawu oluphawulekayo lwe-sarcoidosis into ebizwa ngokuba yi-granuloma. I-Granulomas iqokelelwa kweeseli, phantsi kwe-microscope, zibukeka zifana nezo umzimba ezisetyenziswayo ukulwa nezifo ezifana nesifo sofuba.
Akunabo bonke abantu abane-sarcoidosis kufuna unyango, kwaye kaninzi luya ngaphandle kwonyango, kodwa kwezinye iimeko, kunokukhokelela kwizifo ezinzima. Xa umsebenzi wequmrhu uthintekile, umzekelo, iintlobo ezahlukeneyo zamachiza ezenzelwe ukukhusela isistim somzimba zingasetyenziswa.
Izibonakaliso ezinokuthi zihambelana neziganeko ezichaphazelekayo kwisifo, okanye kunokubakho iimpawu eziqhelekileyo ezifana nokukhathala, umkhuhlane, i-lymph nodes, kunye nokulahleka kwesisindo . Ukubandakanyeka komlenze kuqhelekileyo kwaye iimpawu zingabandakanya ukukhwehlela okuqhubekayo, ukuphefumula okufutshane, ukuvutha okanye ukuhlunguzeka kwesifuba.
Abanye abantu abane-sarcoidosis bahlakulela iimpawu zesikhumba ezifana ne-rash elineebomvu ezibomvu okanye ezimnyama.
Lymphoma
I-Lymphoma enye ye "i-blood cancer", okanye i-hematologic malignancies, igama elibandakanya i- leukemi ne-myeloma . I-Lymphoma ngumhlaza weeseli zamhlophe ze-lymphocyte. Zininzi iintlobo ezahlukeneyo ze-lymphoma.
Uninzi, kodwa kungekhona, i-lymphomas iqale kwi-lymph nodes.
Iindidi ezimbini ezibanzi ze-lymphoma zi-Hodgkin (HL) kunye non-Hodgkin (NHL) lymphoma. Ezi zombini zineentlobo ezininzi kunye neentlobo zingaphakathi, kunye nezixhobo zesifo kunye nezigulane.
Bobabini iHodgkin kunye ne-non-Hodgkin lymphoma inokuchaphazela i-lymph nodes zesifuba-indawo ekufutshane nentliziyo ebizwa ngokuthi i-mediastinum. I-Sarcoidosis iphinda iquka le ndawo.
Sarcoidosis kunye neLymphoma
Kwiminyaka emininzi, abaphandi baye bazibuza ubuhlobo phakathi kwe-sarcoidosis kunye ne-lymphoma. Olu lwalamano luhlala luyimfihlakalo nanamhlanje, ngenxa yezizathu ezininzi.
Ngokweqela labaphandi ababandakanya i-Ishida kunye noogxa nabo, "I-subtype eqhelekileyo ye-lymphoma echaphazelekayo ehambisana ne-sarcoidosis yi-Hodgkin lymphoma, kodwa ihambisa i-B-cell lymphoma enkulu, i-lymphoma ye-follicular kunye ne-myeloma yamaninzi ingabandakanyeka kwi-sarcoidosis-lymphoma syndrome. "Igama elithi" Sarcoid-lymphoma syndrome "laqulunqwa ukuchaza ezi ziphumo.
I-granulomas ephawulekayo ye-sarcoidosis idibeneyo, iqoqo le-immune ejikelezwe ngama-lymphocytes. Kubonakala ngathi, i-lymphomas ngamanye amaxesha inokuhlala "i-granulomas emdlalweni womhlaza." Kwaye le nguqulelo, nangona iyingqabileyo, kucingelwa ukuba mhlawumbi ibonisa indlela yokuzivikela komzimba kwisifo somhlaza, kwaye kungekhona isifo se-systemic, i-sarcoidosis.
Amaphepha atyhicilelwe kwiminyaka embalwa edlulileyo uye yaphawula ukuba ukuhlula phakathi kokusabela kwe-tumor-sarcoidal kunye ne-systemic sarcoidosis inokuba yinkinga.
Bobabini i-sarcoidosis kunye ne-lymphoma banokukwazi "ukukhanyisa" kwi-PET yokuhlola, ukongezelela kwinkimbinkimbi kunye nokuba nakho ukudideka kwelinye iqumrhu kwelinye. Abaphandi bafuna ukuqhubela phambili izifundo zokuhlaziya izicelo zeklinikhi ze-FDG-PET / CT kwizigulane ezine-sarcoidosis.
Ngamafutshane, imibuzo emalunga ne-sarcoidosis-lymphoma syndrome ayiphenduli.
> Imithombo:
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Mellemkjaer L, Pfeiffer RM, Engels EA, Gridley G, Wheeler W, Hemminki K, Olsen JH, Dreyer L, Linet MS, Goldin LR, Landgren O. Izifo ezizimelayo ngabanye kunye namalungu omzimba osondeleyo kunye nokuxhamla kwi-non-Hodgkin lymphoma. Arthritis Rheum . 2008; 58: 657-666.
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I-Heart Heart Lung ne-Blood Institute. Yintoni i-Sarcoidosis? Kufike ngoJanuwari 2016.
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