I-nodular sclerosing I-Hodgkin lymphoma, umhlaza wamaseli e-lymph, uhlobo lwesifo seHodgkin. Luhlobo oluqhelekileyo lwe-Hodgkin lymphoma kumazwe athuthukileyo, u-60 ukuya kuma-80 ekhulwini kubo bonke abantu abachaphazelekayo esi sifo.
I-nodular sclerosing I-Hodgkin lymphoma ithinta kakhulu abantu abaselula kunye nabaselula. Kuqheleke ngakumbi kwiimantombazana kunamakhwenkwe.
Igama elithi 'nodular sclerosing' lithathwe ngokubonakala kwimizimba yellimph node ngaphansi kwe-microscope kulolu hlobo lweHodgkin lymphoma.
Iimpawu eziphambili ze-nodular sclerosing I-Hodgkin lymphoma zandiswe i-lymph nodes entanyeni, emagqabini okanye ngaphakathi kwesifuba . Ukuxilongwa kwe-lymphoma kwenziwa nge-lymph node biopsy.
Uninzi lwabantu lufunyaniswa kwisigaba sokuqala kwaye lunokunyangwa ngonyango olubandakanya i-chemotherapy kunye neyeza.
Enye yeeHodgkin ezahlukeneyo zeLymphomas
Amagama azo zonke iindidi ze-lymphoma kunye neengqungquthela zidibanisa noogqirha abangaboni ngaso rhoqo. Isifo seHodgkin kunye neHodgkin lymphoma sithetha into efanayo, nangona kunjalo, zininzi iintlobo ze-lymphoma, apho iHodgkin inye. Kwaye kukho iintlobo ezahlukeneyo zeHodgkin lymphoma, kwakhona. Ngoko, nantsi ukuhlaselwa kwe-nodular sclerosing i-Hodgkin lymphoma ngokubhekiselele kuyo apho ifanelana khona nomfanekiso omkhulu kunabo bonke i-lymphomas:
Iindidi ezibalulekileyo ze-lymphoma zi- Hodgkin kunye ne-Non-Hodgkin lymphoma.
I-Hodgkin lymphoma inokugqitywa kwakhona ibe ngamaqela amabini:
- I-Classic Hodgkin lymphoma - enamanani amaninzi
- I-lodphocyte e-Nodular-predominant Hodgkin lymphoma
"I-lymphocyte engapheliyo" kunye ne "nodular sclerosing" ayikho into efanayo - ibhekisela kwiintlobo ezimbini ezahlukeneyo zeHodgkin lymphoma.
I-Nodular Sclerosing I-Hodgkin lymphoma - i-lymphoma ngoku kuchazwa-yi-subtype ye-Classic Hodgkin lymphoma. I-Classic Hodgkin lymphoma inamacandelo amane alandelayo:
- Sclerosing
- Iselungelelaniso
- I-Lymphocyte-rich
- I-lymphocyte-iphelile.
Uhlaziyo: I-Nodular Sclerosing Classic Hodgkin Lymphoma
I-Nodular sclerosis I-Hodgkin lymphoma (i-NSHL) yiyona ndlela ixhaphakileyo yinyama-pathology-based subtype phakathi kwabaselula kunye nabantu abadala abasemazweni ashishino. I-NSHL inesici esinexabiso elifa, kunye neengxaki ezili-100 ezikhuselekileyo ezinamawele afanayo.
Kungekudala, kwakukho isifundo esikhulu esenziwa kwintlangano yemisebe ye-ultraviolet ukusuka elangeni kunye neentlobo ezihlukeneyo ze-Hodgkin lymphoma. Kuhlolisiso lukaEmily Bowen kunye noogxa, i-Hodgkin i-lymphoma iziganeko zazincinci kumaqela abantu abane-ultraviolet sun exposure. Nangona oku kufunyanwe kwakungumgangatho, kuphela, lo mkhangeli wawubonakala unyanisekileyo kubantu abane-nodular sclerosis subtype.
Olunye uphando olutshanje luye lwahlolisisa unyango oluthile, ukukhutshwa kwe-immune checkpoint, kunye nendlela enokusebenzisana ngayo neenkqubo ezahlukeneyo ezaziwa ukuba ziyaqhubeka ngeendlela ezithile ze-HL yeklasi.
Uphononongo olwenziwa nguPeter Hollander kunye noogqirha baqaphele ukuba ukukhuselwa komzimba wokulwa nomzimba okujoliswe kwi-receptor ye-death receptor (PD) -1 inendlela yindlela yokwelapha entsha kwi-classic ne-refractory classical Hodgkin lymphoma.
Eli qela lifumene ukuba iimpawu ezithile zeeseli zifunyaniswe ngeenxa zonke i-tumor, kwaye kungekhona kwimizimba ye-tumor ngokwabo, zaxhunyiwe kwi-prognosis. Uphononongo lufumene ukuba iziphumo kwi-classic HL zazibi kakhulu xa ezi iindili zegazi ezimhlophe ezijikelezayo, okanye iiseli ezincinci ze-microenvironment, zazininzi kakhulu ezenza iP-PD 1 ne-PD-L1. Baye bacetyisa ukuba ezi nkqutyana zezigulane zinokuzuza kwiirimimethri zamagqirha ezinamandla kwaye, mhlawumbi, zivela kwi-PD-1 inhibitors njengonyango lwangaphambili.
> Imithombo:
> I-Cozen W, i-Li D, i-Best T, ne-al. Ukuhlaziywa kwe-gene-wide meta-analysis ye-nodular sclerosing I-Hodgkin lymphoma ibonisa ingozi ye-loci kwi-6p21.32. Igazi. 2012; 119 (2): 469-475.
> Hollander P, Kamper P, Ekstrom K, et al. Ubungakanani obuphezulu be-PD-1 + kunye ne-PD-L1 + leukocytes kwi-classical Hodgkin lymphoma microenvironment zidibene nomphumo ongaphantsi. Igalelo legazi. 2017; 1 (18): 1427-1439.
> Bowen EM, Pfeiffer RM, Linet MS, et al. Ubudlelwane phakathi kwemisebe ye-ultraviolet kunye neHodgkin lymphoma subtypes e-United States. IBritish Journal of Cancer. 2016; 114 (7): 826-831.