Uphando olutsha lubonisa ukuba izidakamizwa zesifo somhlaza esibelethwe njenge-letrozole (i-Femara) ingaba yindlela engcono kuneComomid ukuphucula izinga lokukhulelwa kwabasetyhini abane-PCOS. Lezi ziindaba ezilungileyo kwizigidi zabasetyhini abahluphekayo kwi-PCOS, eyona nto ibangela ukuba kungabikho kwintsholongwane e-United States.
UDkt. Richard Legro, u-endocrinologist ozalisayo e-Penn State eHershey Medical Centre wabonisa iziphumo kwi-trial ye-NIH exhaswe yi-NIH ekwinkomfa ka-2012 yama-American Association of Reproductive Medicine (ASRM) eyayibonisa ama-25% ekhulwini labasetyhini abaphathwa nge-letrozole babezalwa ngokuzalwa ukuya kuma-16,8% wabasetyhini abathatha.
Ngokwesiko, iClomid ibe yilisi-mveliso yokuqala ekhethiweyo yokukhuthaza u-ovulation kubasetyhini nge-PCOS kodwa inezinga eliphezulu lokukhulelwa okuphindaphindiweyo kunye nokwandiswa kwe-estrogen. Xa kuthelekiswa, i-letrozole ayinyusisi i-estrogen-njenge-Clomid, inomngcipheko omncinci wokungaqhelekanga kwimizimba kwaye inezinga elingaphantsi lokukhulelwa.
Yintoni i-Letrozole?
I-Letrozole yi- inhibitor ye-aromatase ekhusela ukuguqulwa kwe-androgen kwi-estrogen. Kwakhona kuphucula ubukhulu be-endometri kwaye lukhuthaza ukuphuhliswa kwezinto eziphambili ze-ovarian. Nangona kungagunyazisiwe yi-FDA kule nkqubo, kuboniswe ukuba kubangele ukuvuthwa kwamabhinqa angabonakali. Ngenxa yalesi sizathu, iingcali zengqondo ezingenasifo zisebenzisa izilwanyana kubasetyhini abangenako ukunyamezela okanye abangaphenduli kakuhle kwiClomid.
I-Letrozole yiyilisi esetyenziswa ngokuqhelekileyo ukuphatha izicubu ezixhomekeke kwi-estrogen, ingakumbi umdlavuza wesikhumba kumadala asekudala, abafazi be-menopausal.
Ukuzikhethela:
I-Letrozole ifika kwiiphilisi ezi-2.5mg kwaye ithathwa kanye ngosuku ngosuku lweentsuku ezi-5, ngokuqhelekileyo ziqala ngosuku lwesithathu okanye ngosuku lwesihlanu kwimizuzu yakho yokuhamba . Unokufuna ukubeka iliso ngokusebenzisa iimvavanyo zegazi kunye / okanye i-ultrasounds ukukhetha xa usondela kwi-ovulation.
Imiphumela:
Ngokubanzi, i-letrozole iyakunyamezela.
Iziphumo ezinokuthi zibandakanye:
- ukukhathala
- ukutyeba kwakho
- intloko
- intlungu okanye intlungu
- kushushu
Iingozi zoLwazi lokuzalwa:
Kubalulekile ukuqaphela ukuba le nyilisi ayihambelani nokukhulelwa nokuncelisa. Nangona kunjalo, nceda uqonde ukuba uthatha le chiza phambi kokuba ukhulelwe, ngoko ayiyi kunyusa umngcipheko wokuba nomntwana onesiphako sokuzalwa. I-Letrozole kufuneka imiswe ngokukhawuleza xa ukhulelwe.
Ehlelwe nguComputer ye-PCOS Angela Grassi, MS, RDN
Imithombo:
I-Legro RS, i-Kunselman AR, i-Brzyski RG, i-Casson PR, i-Diamond i-MP, i-Schlaff WD, u-Christman GM, i-Coutifaris C, i-Taylor HS, u-Eisenberg E, i-Santoro N, i-Zhang H. Ukukhulelwa kwi-Polycystic Ovary Syndrome II (PPCOS II) kunye noyilo lwesilingo esincinci esincinci se-random esisisigxina se-clomiphene citrate kunye ne-letrozole kunyango lokusweleka kwabantwana abasetyhini abane-polycystic ovary syndrome. Uvavanyo lweeKlinikhi zeeKlinikhi. Ngomhla ka-2012 uMeyi; 33 (3): 470-81.
I-Nayereh Ghomian, MD, i-Ashraf Khosravi, i-MD, ne-Nezhat Mousavifar, i-MD A i-Randomised Trial Trial ekuqhathaniseni i-Cycle Characteristics Day Two Day Initiation ye-Letrozole Ukwelashwa kwi-Clomiphene I-CPI yokumelana ne-PCOS Iziguli kwii-IUI Cycles. Int J Fertil Steril. 2015 Matshi-Juni; 9 (1): 17-26.