I-Avodart ne-Proscar zivunywe yi-FDA ukuze zonyango iziphumo zonyango lwe-urine kwi- prostate . Igama eliqhelekileyo likaAvodart yi-dutasteride; Igama lesi-generic likaProscar li-finasteride. Le miyeza, nangona kunjalo, inokuba yinkalo enkulu yamanyathelo kunokuba kuphuculwe umsebenzi we-urinary. Basebenza ngokuthintela uhlobo lwe testosterone olubizwa ngokuthi i-dihydrotestosterone (DHT) ejolise kwiprotrate, evuselela ukuba ikhule kwaye ivelise isilwanyana.
Xa i-DHT ivimbile i-prostate gland iyancipha, ukuphucula ukuhamba kwamanzi.
Kukho iziphumo ezinobungozi. Ukuveliswa kwemveliso kudla ngokunciphisa. Ngezinye izihlandlo amadoda axela ukunciphisa i-libido kunye nobungakanani. Kwakhona, ukwandiswa kwebele kunokwenzeka. Ngokuqhelekileyo, le miphumo yecala iya kugqithisa okanye iyancipha ngokude nje ukuba imithi igqitywe kwindawo yokuqala yengubo. Ngaphandle kweenzuzo zokucoca, kukho uluhlu olude lwezinye iingeniso.
Avodart okanye iPscar ikwazi:
- I-PSA ephantsi kunye nokunciphisa umngcipheko wokufumanisa umhlaza wesibeletho
- Ukuphucula izinga lokufumana umhlaza womhlaza wesifo seprotate kumadoda aphantsi kwe-biopsy
- Ubangela umdlavuza we-Gleason 6 (umhlaza wesikolo esiphantsi) ukulungiswa okanye ukucinywa
- I-synergize kunye namanye amayeza asetyenziswa ukunyanga umdlavuza weprotate njengeCasodex okanye iLupron
- Ncedisa ukugcina amadoda ekuhloliseni nokunyusa umngcipheko wokufuna utyando okanye imitha
- Ukunciphisa umbala wesimo somntu
- Ukukhawuleza i-orgasm emadodeni anesigxina se-ejaculation
I-Anti-Cancer Effects
Ngophando olungenamsebenzi ngokuthelekiswa kweProscar kunye ne-placebo, amadoda angama-10,000 ayenzeka nge-prostate biopsy emva kweminyaka emibini yokonyango. Amadoda aphethwe nguPscar afunyaniswa nomhlaza ongama-25% ngaphantsi kokuthelekiswa namadoda aphathwa nge-placebo.
Nangona kunjalo, inzondelelo yokusetyenziswa rhoqo kwePscar ukukhusela umhlaza ngenxa yokuba isifundo esifanayo sichaze i-1% yeziganeko zanda ukuxilongwa komhlaza wesibeletho esiphezulu.
Iingcali ngelo xesha zixhomekeka ukuba uPscar ukhulisa izinga lokufumanisa kunokuba enze izifo eziphezulu. Nangona kunjalo, uPeter Scardino MD, i-urologist eyaziwayo kwiSikhumbuzo iSettering Kettering yashicilela uluvo lokuba iPrascar inokubangela umdlavuza ophezulu, ukuphakamisa zonke iintlobo zokuxhatshazwa nokukhuthaza i-FDA ukuba ibeke isilumkiso. Zonke ezo ntshutshiso zagqitywa ngomhla we-Agasti 15 we-2013 we-New England Journal of Medicine eyayingabonanga ukwanda komdlavuza wesifo se-prostate kumadoda aphathwe ngo-Proscar xa kuthelekiswa namadoda aphathwa nge-placebo emva kweminyaka eyi-18 yokubonwa.
Ukususela kumsebenzi we-Avodart kunye neProscar ngeendlela ezifanayo, ininzi yento eyaziwa ngeproscar inokuthiwa ngo-Avodart. Zombini ii-agent zithintela i-5- alpha-reductase (5-AR), i-enzyme eguqula i-testosterone ibe yi-DHT. Kukho inzuzo yokufunda i-Avodart ngaphezu kwe-Proscar kuba i-Avodart inqanda i-enzyme eyi-5-AR ngokucace ngakumbi. Nangona kunjalo, akukho zilingo zeklinikhi, zenzelwe ukuthelekisa ezi ntloko zentloko.
Ekubeni i-Proscar kunye ne-Avodart ephantsi kwe-PSA malunga ne-50%, umbuzo uvela, "Ngaba bayabamba amandla e-PSA ukubonisa ukuqhubela phambili komhlaza?" Ngokufutshane, impendulo ayikho. La mayeza awayekiyo i-PSA ekukhuphukeni kwamadoda anomdlavuza oqhubekayo. Nangona kunjalo, i-PSA ibuye isetyenziswe kwizinga elingaphantsi kwe-50% emva kokuqalisa iPscar okanye i-Avodart. Ngokomyinge, indoda enePSA ye-6.0 ngaphambi kokuqalisa iPscar iya kuhlahlela kwi-3.0 zingangeenyanga ezimbalwa. Emva koko, ukuba i-PSA iphakama rhoqo ngaphezu kwe-3.0, ukuqhubela phambili komhlaza kufuneka kuhanjiswe njengesona sizathu.
I-Proscar ne-Avodart inomdla wokuba nemiphumo emibi kwaye kukho ezimbalwa ukuba kukho ukusebenzisana namanye amayeza.
Xa iziphumo zecala zivela, zivame ukuguqulwa. I-Proscar ne-Avodart zikulungele kuba ziyakuthathwa naliphi ixesha lomhla, kunye okanye ngaphandle kokutya. I-Finasteride, i-generic ye-Proscar iyatholakala kwaye ifikeleleke kakhulu. Iindleko ezilungileyo kunye nefuthe lenkqubela ecaleni lenza ukuba kuqwalaselwa ngokuthe ngqo kwizigulane zomhlaza wesibeletho ezifuna ukulawula i-PSA ngenkathi ziqhubeka nokugcina umgangatho omhle wobomi ngeendleko eziphantsi.