Njengoko iiseli zegazi zikhula, "iintsapho" ezahlukileyo zivela kwii-cell stem cells. Umgca weeselidi weselfayile umela enye intsapho. Iiseli kumgca weeselidi eselunxwemeni yizo ezivela kwiiseli ze-proyeloid ze-cell, kwaye ekugqibeleni ziza kuba ngamaseli endala adala asekudala, aboniswe apha:
- Basophil
- Neutrophils
- Eosinophils
- I-Monocytes (ekhoyo egazini)
- I-Macrophages (ekhoyo kwiimveliso ezihlukeneyo)
- I-Erythrocytes (amangqamuzana egazi obomvu)
Ngaloo ndlela, nganye intlu zeentlobo ezingentla zimela umkhiqizo wokugqibela okanye umphumo wokukhula kwintsapho ekhusayo.
Ingumgca weselfowuni esithintekayo kwi-"malignedings" efana ne- acute leememiaid (i-AML) , enesifo esiphezulu se-diagnostic ngonyaka, kunye ne-lemonem ye-myelogenous (CML) engapheliyo. unyaka e-United States.
Umxholo
Iiseli ezibomvu , iiseli zegazi ezimhlophe, kunye neeplatelets zonke zizinzile izilwanyana zobomi, kwaye zitshintshwa ngokuqhubekayo. Amaseli e-blood-forming - ahlala kakhulu kumnatha wethambo kubantu abadala - ukwandisa nokuvelisa abantu abahlukeneyo, okanye imigca yeeseli.
Zonke iiseli zegazi ezikhulile zilandelelanisa umgca wazo kumqolo wesinye, i-hematopoietic stem cell (HSC), into efana "noAdam noEva" kuwo onke amaseli egazi.
Lezi zisele ze-stem zahlula - zombini ukuba zenzele indawo yazo kwaye zenze "iiseli zangasemva." Phakathi kwenzalo ye-HSC ke ke iintlobo ezahlukeneyo zeeseli ezingama-progenitor: kukho umntu ongenayo i-lymphoid progenitor kunye nomntu oqhelekileyo we-myeloid. Le foloko endleleni phakathi kwelayini ye-lymphoid ne-myeloid yintloko.
Umntu ngamnye ongenakho unokuvelisa iintsapho zakhe ezihlukeneyo zeeseli zegazi. Amaseli egazi ezimhlophe aziwa njenge-lymphocyte zivela kwi-lymphoid progenitors, ngelixa iindidi zegazi ezimhlophe ezahlukahlukeneyo, iiseli ezibomvu zegazi kunye neeplatelet zivela kwi-progenitors. Amaseli omgca we-myeloid ngokuqhelekileyo akhiqiza malunga nama-85% omnxeba weerrow, ngokupheleleyo.
Izidloviso ezingummiselo
Ngokutsho kwe-American Cancer Society, ezininzi izigulane ezine-leukemia (i-AML) ezinomzimba omhlophe kakhulu zininzi ezimhlophe ezimhlophe kwigazi labo, kwaye azikho iiseli ezibomvu zegazi okanye iiplatelets. Uninzi lwamaseli egazi ezimhlophe lunokuba yi-myeloblasts - ngokuqhelekileyo kuthiwa yi- blasts-eyimizimba eyenziwa yintsholongwane yamanzi engabonakaliyo kwigazi elijikelezayo. Ezi iiseli ezifayo azisebenzi njengeziqhelo eziqhelekileyo ezimhlophe zegazi.
Uninzi lwezigulane ezine-leukemia ezingapheliyo (i-CML) zininzi zamaseli egazi ezimhlophe ezininzi, zangaphambili. Ezinye zeeseli ezimhlophe ezingapheliyo ziyakwazi ukuqhuma kodwa zihlala zikhona kwinani elincinci kune-AML. Ngamanye amaxesha izigulane ze-CML zinokuba neenombolo eziphantsi zeeseli ezibomvu zegazi okanye iiplatelet zegazi.
Kuzo zombini i-AML kunye ne-CML, ukubalwa kweeseli zegazi kungabonakalisa i-leukemia, kodwa ukuxilongwa okucacileyo kudinga umongo we-bone ne-aspirate kunye nezinye iimvavanyo.
Imithombo
Krumsiek J, Marr C, Schroeder T, et al. Ukwahlukana kwamaHerarchical of Proyeloitors aseMyeloid Ikhokhelwe kwiNethiwekhi yeTranscription Factor. PLoS One. 2011; 6 (8): e22649.
Eaves CJ. Amaseli ase-Hematopoietic stem: iingcinga, iinkcazo, kunye nenyaniso entsha. Igazi . 2015; 125 (17): 2605-2613.
Orkin SH, iZon LI. I-Hematopoiesis: I-Paradigm yokuguqulela i-Cell Stem Biology. Cell . 2008; 132 (4): 631-644.
Jagannathan-Bogdan M, Zon LI. Hematopoiesis. Uphuhliso (iCambridge, eNgilani) . 2013; 140 (12): 2463-2467.
American Cancer Society. Unjani i-leukemia ephawulekayo? Kufike ngoDisemba 2015.
UWilliam, uL. "Ukuhlaziywa ngokubanzi kwe-Hematopoiesis kunye ne-Immunology: Impembelelo yabamkeli be-Hematopoietic Stem Acplantants" kwi-Ezzone, S. (2004) I-Hematopoietic Stem Cell Transplantation: Umhlahlandlela woLondolozo lwe-Oncology Society Nursing: Pittsburgh, PA (iphe.1- 12).