Ziziphi iziyobisi eziphuhliswayo Ukuphatha i-Crohn's and Ulcerative Colitis?
Kwiminyaka yakutshanje, unyango lwe- inflammatory disease bowel (IBD) luye lwaqwalaselwa ngakumbi kwiinkampani zonyango kunye nabaphandi. Ixesha elizayo kubantu abane-IBD likhanya ngakumbi kunanini ngaphambili, njengoko ezinye iziyobisi zikhona kumbhobho ukuphatha ezi zifo ezikhubazayo kunye neengxaki ezihambelana nazo.
Alicaforus
I-allicaforsen okwangoku ilayisenisi yeAlantic Pharmaceuticals Limited.
Isilwayo senziwa yi- enema kwaye sivavanywa ukusetyenziswa kwi-ulcerative colitis ne- pouchitis . I-allicaforsen inikwe i-orphan drug status kwi-United States kunye ne-European Union.
UAlequel
U-Enzo Biochem uqedile uAlequel kwizigulane ezinokulinganisela kwisifo esibi seCrohn. Isilwayo yonyango olwenziwe ngumntu we-extract-containing containing it is created from tissue from colon patient and administered orally. Ukuxolelwa kwafezwa ngama-50 ekhulwini kwezigulane kwiziyobisi, ngokumalunga nama-33 ekhulwini kunye ne-placebo. Isilwanyana sasinyamezeleka, kungekho miphumo emibi.
Teduglutide
Eli qela elitsha liqhutyelwa ukuba lisetyenziswe kuzo zombini i-IBD kunye ne- short-bowel syndrome (SBS) . I-SBS yimeko edala isifo sohudo, ukuqhaqhaqhaqhaqhaqhaqha, ukuqhaqhaqhaqha, kunye nokukhwabanisa okwenzeka kubantu abaye banesigamu (okanye ngaphezulu) samathumbu abo amancinci . Isizathu esiqhelekileyo se-SBS senziwa ngokuphindaphindiweyo kokuhlinzwa okwenziwa ukusetyenziswa kwesifo sika-Crohn.
Imiphumo emibi ye-teduglutide ibonakala iyinto encinci, njengoko imiphumo ibonakala ngokuyinhloko kumathambo emathumbu. Abantu abane-SBS abathatha inxaxheba kwilingo le-teduglutide babonise zombini ukwandisa izondlo kunye nesisindo somzimba. Imiphumo emibi echazwe ngokuqhelekileyo yayiquka intlungu yesisu, intloko yesifo, iinguqu zesisu kunye nokuvuvukala.
I-NPS Pharmaceuticals, umphuhlisi we-teduglutide, igqibe ukufundwa kweengqinisiso-mfundiso kwizigulane ezinezifo zikaCrohn. Kwizigulane ezine-Crohn's, ama-55 ekhulwini aphumelele ukuxolelwa emva kweeveki eziyi-8 zokusebenzisa iziyobisi, xa kuthelekiswa neepesenti ezingama-33 zezigulane ezifumana indawo ye-placebo. Iyona mpembelelo eyingozi kakhulu ebhengeziweyo yayibomvu kwindawo yokujola. Olunye uphando luqhutyelwa kwizigulane ezineSBS.
I-Teduglutide iye yanikwa isimo seziyobisi zeenkedama eMelika naseYurophu ngokusetyenziswa kwayo kwi-SBS. I-NPS okwangoku ifuna iqabane lophuhliso ukuqhubeka nokuvavanya iilisi ukuze isetyenziswe kwisifo sikaCrohn.
I-Traficet-EN (CCX282)
I-Traficet-EN iyi-anti-inflammatory small molecule yezokwelapha okwangoku ihlolwe ukusebenzisa kwisifo sikaCrohn ngumenzi we-ChemoCentryx. Kwisilingo samva (I-PROTECT-1), ipesenti enkulu yezigulane ezifumana iziyobisi ziphumelele ukuxolelwa emva kweeveki ezingama-36 kunezo ezifumene indawo ye-placebo. Isilwanyana sazinyamezeleka phakathi kwabathathi-nxaxheba kwi-trial yeenyanga ezili-12.
Imithombo:
ChemoCentryx. "Inkqubo yeCCR9.". 2010. 26 Juni 2010.
Enzo Biochem, Inc. "uAlequel." . 2010. 26 Juni 2010.
Isis Pharmaceuticals, Inc. "Izifo ezivuthayo." . 2010. 26 Juni 2010.
IMargalit M, i-Israel E, i-Shibolet O, i-Zigmond E, i-Klein A, i-Hemed N, i-Donegan JJ, i-Rabbani E, i-Goldin E, i-Ylan Y. Iiprotheni ezikhutshwe ngekoloni: indlela yokugulisa isigulane. " InguJ Gastroenterol Matshi 2006 101: 561-568. 26 uJuni 2010.
NPS Pharmaceuticals. "Amathuba okusebenzisana kweNPS." 2010. 26 Feb 2012.