Ukuqonda ukuphikisana kwi-Afrika (i-Endemic) kunye ne-Spradic Burkitt's Lymphoma
Yiyiphi i-lkphom yeBurkitt, zeziphi izizathu, kwaye ziphathwa njani?
Sibanzi
I-Burkitt's lymphoma (okanye i-Burkitt Lymphoma) uhlobo olungavamile lwe- Non-Hodgkin Lymphoma (NHL) . I-Burkitt's lymphoma ixhaphaza abantwana. Uhlobo olushushu kakhulu lwe-B-cell lymphoma edla ngokuqala kwaye lubandakanye izitho zomzimba ngaphandle kweelymode . Nangona iimeko ezikhula ngokukhawuleza, i-lkphoma ye-Burkitt ihlala iphilisa kunye neendlela ezinzulu zokwelapha.
Iintlobo
Kukho iintlobo ezimbini ezibanzi ze-Burkitt's lymphoma - iintlobo ezinqamlekileyo kunye neentlobo eziphilayo. Kukho iziganeko eziphezulu kakhulu kwesi sifo kwi-equatorial Afrika, kwaye izifo kule ndawo zibizwa ngokuba yi-lkphoma yeBurkitt. Izifo kwezinye iindawo zehlabathi ziphantsi kakhulu kwaye zibizwa ngokuba yi-lkphoma yeBurkitt. Nangona isifo esifanayo, ezo zimbini ziyahluka ngeendlela ezininzi.
Ubunzima (iAfrika) iLymphoma yeBurkitt
E-Afrika ye-equatorial, malunga nesiqingatha sazo zonke iintsholongwane zomntwana zingama-lymphomas kaBurkitt. Esi sifo kubandakanya abantwana abaninzi kunabantu abadala kwaye uhambelana nosulelo lwe-Epstein-Barr Virus (EBV) kwiimeko ezingama-98%. Ingumntu unalo ithuba eliphezulu lokubandakanya umhlathi, into ebonakalayo eyahlukileyo engaqhelekanga kwi-Burkitt. Ngokuqhelekileyo kubandakanya isisu.
I-Lymphoma ye-Burkitt ye-sporadic
Uhlobo lwe-Burkitt's lymphoma oluchaphazela lonke ihlabathi, kuquka iYurophu kunye ne-America luhlobo oluthile.
Nalapha, kubaluleke kakhulu isifo kubantwana, kuba noxanduva malunga nesithathu se-lymphomas kubantwana base-United States. Ikhonkco phakathi kwe-Epstein-Barr Virus (i-EBV) ayinamandla njengobuninzi beentlobo, kodwa ubungqina obuchanekileyo bokusuleleka kwe-EBV bukhona kwisigulane esisodwa kwezihlanu. Ngaphandle kokubandakanyeka kwee-lymph nodes, yisisu esisithinteka kakhulu kwi-90% yabantwana.
Ukubandakanyeka komnxeba we-Bone kuqhelekile kunokuba kuluhlu lweentlobo. Ukubandakanyeka kwe-Jaw kubonakala kunqabile.
Iintlobo eziqhelekileyo eziqhelekileyo
Iifom ezimbini ezingaphantsi kweBurkitt's lymphoma ziquka:
- Uhlobo oluphakathi, oluneenkalo zombini we-Burkitt's lymphoma kunye nolwazi olubanzi lwe-B-cell lymphoma .
- I- Lymphoma ehlangene ne- HIV , enxulumene nosulelo lwe-HIV.
Amanqanaba
Esi sifo sinokuphulwa phantsi ngokulula kwiinqanaba ezi-4 ezahlukeneyo (inqaku: oku akuphelelanga kwaye kungahle kuqhutywe kwezinye iimeko.)
Isigaba I - Isigulane sam isifo kuthetha ukuba umhlaza ukhona kwisiza esisodwa kumzimba.
Isigaba II - I-Stage II I-lymphomas yeBurkitt ikhona kwiindawo ezingaphezu kweyodwa, kodwa zombini izingosi zihlangothini olunye lwesalathisi .
Isigaba III - Isifo se-Stage III sikhona kwii-lymph nodes okanye ezinye iindawo kumacala omabini.
Isigaba IV - Isifo se-Stage IV siquka i-lymphomas efunyenwe emnzini wethambo okanye kwingqondo (inkqubo ephakathi kwenzwa.)
Izizathu kunye neengozi
Njengoko kuphawuliwe ngasentla, i-Epstein-Barr idibene neninzi yamatyala e-Burkitt's lymphoma, kunye nezinye izifo zesifo esiphambanisayo. Ukuxilongwa ngokungaxilwanga kusemngciphekweni, kwaye eAfrika, kucingelwa ukuba i-malaria ingabangela abantwana ukuba babe neengozini enkulu kwi-Epstein-Barr virus.
Unyango
I-Burkitt ye-lymphoma iyisisu esinamandla, kwaye isoloko isongela ubomi. Kodwa enye yindlela ephilisa ngakumbi ye-lymphoma. Ukuqonda oku kunceda ukuqonda ukuba ukuhlaselwa kwekhemotherapy iiseli ezihlukana ngokukhawuleza. Ikhono lokusebenzisa i-chemotherapy lenze enye ye-lymphoma enobudlova kunye ne-leukemia yexesha elidlulileyo, elona lonyango kakhulu kwaye lingaphiliswa ngexesha langoku.
Ngeendlela ezixhaphakileyo zamachiza e-chemotherapy ezisebenzisa iziyobisi kumayeza aphezulu, kunye nokufumaneka kwamanyathelo amasha okuxhasa abantu ngexesha lokunyanga okukhulu, le lymphoma iphilisa kwizigulane ezininzi.
Ngokubanzi phantse i-80% yabantu abanezifo ezikhoyo kwaye ngaphezulu kwesigamu sabantwana abanesifo esasasazekayo baphiliswa. Ukubuyela emva kwexesha kungekudala.
Prognosis
Isibhengezo seBurkitt's lymphoma eUnited States siphucule ngokukodwa kwiminyaka yamuva. Phakathi kuka-2002 no-2008 umlinganiselo wokusinda kweminyaka emi-5 usuka kwi-71 ukuya kwi-87% kubantwana phakathi kokuzalwa kunye ne-19 ubudala. Kwabo abaneminyaka engama-20 ukuya ku-39, izinga lokusinda liphucukile ukusuka kwi-35 ukuya kwi-60%, kwaye kwizigulane ezingama-40 ezongezelelekileyo zokusinda zenza ngcono. Ukususela kulo xesha uphuculo olongezelelweyo kunyango, kwakunye nokulawulwa kwemiphumo emibi, kwenzeke.
Ukujamelana
Ingangethusa ukuba ifumane i-lymphoma, kwaye yimbi ngakumbi ukuba ngumntwana wakho ofunyaniswayo. Ukukhulisa umntwana kuthatha idolophana kuqala, kodwa uya kufuna inkqubo yakho yenkxaso kunanini ngaphambili. Finyelela kwabanye. Le ngqumbo ayinqabile, kodwa nge-media media, kukho indawo esebenzayo ye-intanethi yabantu abajongene nesi sifo onokungena kuyo kunye ne-24/7 ukuxhasa. Imibutho ye-Lymphoma kunye ne-leukemia inokukunceda ngakumbi ngeyona ndlela.
Imithombo
Coghill, A., no-A. Hildesheim. I-epstein-Barr i-antibodies virus kunye nomngcipheko weentlondi ezinxulumene nazo: ukuhlaziywa kweencwadi. I-American Journal ye-Epidemiology . 2014. 180 (7): 687-95.
ICosta, uL., Xavier, A., Wahlquist, A., no-E. Hill. Iintlobo zokusinda kwezigulane ezine-Burkitt lymphoma / leukemia e-USA: uhlalutyo lwamacala angama-3691. Igazi . 121 (24): 4861-6.
Dunleavy, K., Pittaluga, S., Shovlin, M, et al. Unyango olusisiseko olunzulu kubantu abadala abane-Burkitt's lymphoma. I-New England Journal of Medicine . 2013. 369 (20): 1915-25.
National Cancer Institute. I-PDQ yengxelo yeCcercer Information Summaries. Unyango lwe-Non-Hodgkin Treatment Lymphoma (PDQ). INgxelo yezobuGcisa. 09/29/15. http://www.ncbi.nlm.nih.gov/books/NBK65738/#CDR0000062808__1